A graphic depiction of the evolution of evolutionary theories (A) and an example of recent evolutionary genomics study in which a positively selected gene found in giraffes can result in high bone density and resistance to hypertension (B) [32]. The question mark indicates that I am not sure that if the “Grand synthesis” is a proper name or not for the current evolutionary biology. The case in (B) vividly shows that the evolutionary genomics approach proposed in this paper can have great power to reveal molecular mechanism underpinning an important trait and enlighten future biomedical research in hypertension and osteoporosis [32].