Natl Sci Open
Volume 1, Number 1, 2022
Special Topic: COVID-19: Virus, Immunity and Vaccines
|Number of page(s)||15|
|Section||Life Sciences and Medicine|
|Published online||24 March 2022|
Anti-viral memory T cell responses in the absence of IgG production in a COVID-19 convalescent individual
Institute for Immunology and School of Medicine, Tsinghua University, Beijing 100084, China
2 Center for Human Disease Immuno-monitoring, Beijing Friendship Hospital, Beijing 100050, China
3 Department of Hematology, Chui Yang Liu Hospital Affiliated to Tsinghua University, Beijing 100022, China
4 Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China
5 Department of Cardiology,Chui Yang Liu Hospital Affiliated to Tsinghua University, Beijing 100022, China
6 Shanghai Immune Therapy Institute, Shanghai Jiaotong University School of Medicine-affiliated Renji Hospital, Shanghai 200127, China
Revised: 17 December 2021
Accepted: 27 December 2021
Cellular and humoral immunity are both important in host defense against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although defects in SARS-CoV-2-specific T cell immunity have been found in patients with severe lung pathology, it is still largely unclear whether virus-specific T cells are sufficient for host protection. Here, we found that in a previously characterized cohort of convalescent subjects, one individual, though lacking detectable anti-viral neutralizing IgG antibodies, showed virus-specific T cell responses, both in CD4+ and CD8+ T cells. SARS-CoV-2-specific T cells in this and other individuals are maintained for up to 10 months. This study thus further supports a critical role of T cells in host defense against SARS-CoV-2, offering new insights into the design and evaluation of COVID-19 vaccines.
Key words: SARS-CoV-2 / adaptive immunity / T cells / memory
© The Author(s) 2022. Published by China Science Publishing & Media Ltd. and EDP Sciences.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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