Figure 2

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(A) The structure of the TAL effector with DNA substrate (PDB ID: 3UGM). (B) The interactions between 4 kinds of TALE repeats with different RVDs and corresponding base pairs. The RVDs and base pairs are shown in sticks. Dashed lines indicate H bonds. The HD, NG, and NI RVDs are derived from PthXo1 (PDB ID: 3UGM). The NH RVD is derived from engineered TALE Hax3 (PDB ID: 4OSL). (C) Schematic diagram of TALEN. TALE modules are indicated in different colors, with the corresponding base shown in the same color.
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