Figure 6

Download original image
The potential engineered tools for genome editing. (A) Combining the reverse transcriptases (RTs) from retrotransposon with TALEN or CRISPR system may overcome the limitation of specific recognizing motifs by RTs. Or we can evolve new RTs that have less strict recognizing motifs. (B) The Ago system can provide specific targeting for precise editing, relying on the complementation of ssDNA or RNA with the locus regardless of PAM. Compared with CRISPR, its relatively weak cleavage ability will reduce the hazards of off-target cleavage events. (C) AI-assisted protein design may be able to generate proteins with higher targeting specificity, efficiency, and low redundancy.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.